
When the gregarious mice were later put in the cage and the tone was played, they showed clear physiological signs of aversion (like freezing in place), even though they were never shocked. These mice had learned to associate the tone and the cage with something negative; the squeaking mouse taught them that the tone predicted distress. When the researchers tried the experiment again, this time with mice from a genetically different strain that is less social, they found that the mice didn’t show any response to the tone once inside the cage. In other words, they didn’t respond to the other mouse’s distress.
“The core of empathy is being able to have an emotional experience and share that experience with another,” says University of Wisconsin-Madison graduate student Jules Panksepp, who worked on the study. “Deficits in empathy are frequently discussed in the context of psychiatric disorders like autism. We think that by coming up with a simplified model of it in a mouse, we’re probably getting closer to modeling symptoms of human disorders.”
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